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William J Martin Selected Research

Sodium Channel Blockers

12/2010Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain.
3/2008Imidazopyridines: a novel class of hNav1.7 channel blockers.
4/2007Sodium channel blockade may contribute to the analgesic efficacy of antidepressants.
4/2007Relationship between the firing frequency of injured peripheral neurons and inhibition of firing by sodium channel blockers.
3/2006Block of peripheral nerve sodium channels selectively inhibits features of neuropathic pain in rats.
6/2005Discovery of potent and use-dependent sodium channel blockers for treatment of chronic pain.
4/2005Novel cyclopentane dicarboxamide sodium channel blockers as a potential treatment for chronic pain.
8/2004A disubstituted succinamide is a potent sodium channel blocker with efficacy in a rat pain model.

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William J Martin Research Topics

Disease

11Neuralgia (Stump Neuralgia)
12/2010 - 02/2003
9Pain (Aches)
03/2013 - 02/2002
4Inflammation (Inflammations)
01/2020 - 02/2003
4Infections
11/2016 - 11/2005
4Hyperalgesia
04/2010 - 12/2004
3Tuberculosis (Tuberculoses)
01/2017 - 03/2002
3Neoplasms (Cancer)
10/2014 - 01/2002
3Asthma (Bronchial Asthma)
11/2012 - 11/2012
3Chronic Pain
09/2009 - 04/2005
2Wounds and Injuries (Trauma)
01/2020 - 02/2003
2Rheumatoid Arthritis
12/2018 - 09/2014
2Chronic Obstructive Pulmonary Disease (COPD)
10/2014 - 10/2012
2Lung Injury
09/2012 - 08/2011
2Fibrosis (Cirrhosis)
09/2012 - 08/2011
2Body Weight (Weight, Body)
08/2011 - 02/2003
2Hypersensitivity (Allergy)
06/2005 - 05/2004
2Weight Gain
02/2003 - 01/2003
1Mental Disorders (Mental Disorder)
01/2021
1Traumatic Brain Injuries (Traumatic Brain Injury)
01/2020
1Alcoholism (Alcohol Abuse)
01/2019
1Major Depressive Disorder (Major Depressive Disorders)
01/2019
1Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder)
01/2019
1Myocarditis (Carditis)
12/2018
1Rheumatic Fever (Acute Articular Rheumatism)
12/2018
1Rheumatic Heart Disease (Rheumatic Heart Diseases)
12/2018
1Autoimmune Diseases (Autoimmune Disease)
12/2018
1Sarcoidosis (Schaumann Disease)
12/2017
1Type 2I Limb-Girdle Muscular Dystrophy
01/2017
1Muscular Dystrophies (Muscular Dystrophy)
01/2017
1Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy)
01/2017
1Anemia
01/2016
1Nasopharyngeal Neoplasms (Cancer of the Nasopharynx)
10/2014
1Lung Neoplasms (Lung Cancer)
10/2014
1Cardiovascular Diseases (Cardiovascular Disease)
05/2013
1Pneumonia (Pneumonitis)
08/2011
1Necrosis
04/2009
1AIDS-Related Complex (ARC)
04/2009
1Epilepsy (Aura)
03/2008
1Diabetic Neuropathies (Diabetic Neuropathy)
04/2007

Drug/Important Bio-Agent (IBA)

8Sodium Channel BlockersIBA
12/2010 - 08/2004
6Sodium Channels (Sodium Channel)IBA
03/2009 - 06/2005
3AllergensIBA
11/2012 - 11/2012
3Voltage-Gated Sodium ChannelsIBA
09/2010 - 03/2009
2Proteins (Proteins, Gene)FDA Link
01/2017 - 11/2005
2InterferonsIBA
01/2017 - 11/2016
2Coal (Coals)IBA
10/2014 - 05/2013
2Bleomycin (Blenoxane)FDA LinkGeneric
09/2012 - 08/2011
2Voltage-Gated Sodium Channel BlockersIBA
09/2009 - 06/2005
2Peptides (Polypeptides)IBA
04/2009 - 08/2002
2Tetrodotoxin (Tetradotoxin)IBA
03/2009 - 06/2005
2Lamotrigine (Lamictal)FDA LinkGeneric
04/2007 - 09/2005
2Analgesics (Analgesic Drugs)IBA
02/2003 - 01/2003
2Opioid Analgesics (Opioids)IBA
02/2003 - 01/2003
2flunixinIBA
02/2003 - 01/2003
2Buprenorphine (Subutex)FDA LinkGeneric
02/2003 - 01/2003
2DNA (Deoxyribonucleic Acid)IBA
07/2002 - 01/2002
1Immunoglobulin G (IgG)IBA
01/2020
1C-Reactive ProteinIBA
01/2020
1Biogenic Amines (Biogenic Amine)IBA
01/2019
1Antidepressive Agents (Antidepressants)IBA
01/2019
1LY2940094IBA
01/2019
1Neurotransmitter Agents (Neurotransmitter)IBA
01/2019
1Opioid Peptides (Opioid Peptide)IBA
01/2019
1Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA
12/2018
1Hydroxychloroquine (Plaquenil)FDA LinkGeneric
12/2018
1CytokinesIBA
12/2018
1Biomarkers (Surrogate Marker)IBA
12/2017
1Virulence Factors (Pathogenicity Factors)IBA
01/2016
1Bronchodilator Agents (Bronchodilators)IBA
10/2014
1Etanercept (Enbrel)FDA Link
09/2014
1Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA
10/2012
1Liposomes (Liposome)IBA
08/2011
1pyrazoleIBA
12/2010
1diphenyl (biphenyl)IBA
12/2010
1compound 20IBA
12/2010
13- (5- nitrofuryl)- 7- (5- nitrofurfurylidene)- 3,3a,4,5,6,7- hexahydro- 2H- indazoleIBA
09/2010
1CarrageenanIBA
04/2010
1Freund's AdjuvantIBA
04/2010
1IsoxazolesIBA
09/2009
1Silicon Dioxide (Silica)FDA LinkGeneric
06/2009
1CollagenIBA
04/2009
1Neuropeptide YIBA
04/2009
1Glucose (Dextrose)FDA LinkGeneric
04/2009
1NAV1.9 Voltage-Gated Sodium ChannelIBA
03/2009
1Tricyclic Antidepressive Agents (Tricyclic Antidepressants)IBA
04/2007
1Desipramine (Pertofrane)FDA LinkGeneric
04/2007
1Nortriptyline (Aventyl)FDA LinkGeneric
04/2007
1Amitriptyline (Elavil)FDA LinkGeneric
04/2007
1Lidocaine (Xylocaine)FDA LinkGeneric
04/2007
1Maprotiline (Ludiomil)FDA Link
04/2007
1Fluoxetine (Prozac)FDA LinkGeneric
04/2007
1Imipramine (Janimine)FDA LinkGeneric
04/2007
1Carbamazepine (Tegretol)FDA LinkGeneric
04/2007
1Zimeldine (Zimelidine)IBA
04/2007

Therapy/Procedure

3Therapeutics
01/2021 - 12/2005
3Ligation
03/2013 - 03/2008
2Analgesia
01/2013 - 01/2003
2Oral Administration
04/2010 - 09/2005
1Biological Therapy
09/2014
1Intravenous Administration
04/2007